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PBPK Modeler

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About PhinC Development

PhinC Development is the expert partner for small to medium sized pharmaceutical or biotech companies, who need to move forward in early drug research. Thanks to a multidisciplinary team with thorough field experience, PhinC Development helps to take the best decisions concerning drug development using all existing pharmacology and pharmacometrics modeling & simulation (M&S) tools (PBPK, PopPK, PKPD and simulations). Becoming part of our team will give you hands-on experience and the chance to:

  • Work in a dynamic environment
  • Be in a company in which innovation, people and entrepreneurship are the fundamentals of its success

Challenges

Your Responsibilities include:

  • Develop and execute scientifically sound, innovative and business-oriented Modeling & Simulation (M&S) strategic plans for projects in various disease areas and different stages of product development, including regulatory submissions
  • Develop and execute appropriate PBPK models in the context of drug development
  • Conduct simulations to inform drug development decisions such as in vitro in vivo extrapolation, drug-drug interaction, formulation studies, simulations in special populations, dose regimen selection and other trial design features
  • Communicate the outcome of M&S analysis to sponsors to support efficient discussion and decision making
  • Contribute to responses to health authority requests and interactions to align on Clinical development and M&S strategy
  • Interact on a scientific level with sponsors with regards to all aspects of the application of M&S to ensure efficient and appropriate integration of M&S strategy and results into project.

Your profile

  • You either hold a PhD and/or a master’s degree in a relevant area (PBPK, pharmaceutical sciences or other related scientific discipline) and have already worked with PBPK modeling software such as GastroPlus, PK-sim or any other PBPK software. Knowledge in Phoenix WinNonLin, Monolix or NONMEM will be an asset.
  • You have at least 1 year of experience in PBPK modeling (mandatory).
  • You are fluent in English both orally and written, have good communication and presentation skills, scientific rigor and motivation.
  • You have a strong desire to further develop and apply modeling and simulation in drug development and appreciate working in teams of scientists with different backgrounds,

Job Type: Full-time Contract (permanent)

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