Oroxcell – DPRA with LC-MS/MS, a reliable method for sensitization-potential assessment of complex mixtures.

DPRA with LC-MS/MS : A way forward for botanical extracts. The DPRA assay is a widely used test to identify potential haptens that undergo a chemical reaction with endogenous proteins, the first key event of skin sensitization. It is described in the OECD Test Guideline 442C and exhibits state-of-the-art prediction performance levels, especially when [...]

13 avril 2018|Catégories : Actus membres|Tags : |

Oroxcell – [MN3D] In vitro topical genotoxicity assessment : New assay available

After 3 years of intensive research in collaboration with Nestlé Skin Health (Galderma), the Oroxcell team succeeded in developing a Cytokinesis-Block Micronucleus Assay using Episkin LM™ Reconstructed Human Epidermis (MN3D assay). During the proof of concept testing the method achieved an excellent prediction accuracy of 80% with a set of substances containing progenotoxins known [...]

21 mars 2018|Catégories : Actus membres|Tags : |